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Acknowledgements Members of the PATCH study group are: Jing-Long Huang (Study Coordinator), Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Man-Chin Hua, Shen-Hao Lai, Kuo-Wei Yeh, and Li-Chen Chen (Principal Investigators)

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Although research is emerging around e-cigs in general, there continues to be a lack of scientific evidence regarding the safety and risks of e-cig use on maternal and fetal health, even though adverse health effects of nicotine on maternal and fetal outcomes are documented e-cigarettes, often touted as a safer alternative to cigarette smoking, may modify the DNA in the oral cells of users, potentially increasing the risk of cancer